The AIM2 inflammasome is critical for innate immunity to Francisella tularensis
نویسندگان
چکیده
منابع مشابه
Innate Immunity: Cytoplasmic DNA Sensing by the AIM2 Inflammasome
Cytoplasmic double-stranded DNA triggers cell death and secretion of the pro-inflammatory cytokine IL-1beta in macrophages. Recent reports now describe the mechanism underlying this observation. Upon sensing of DNA, the HIN-200 family member AIM2 triggers the assembly of the inflammasome, culminating in caspase-1 activation, IL-1beta maturation and pyroptotic cell death.
متن کاملMvin mediates Francisella Tularensis virulence through evasion of AIM2 inflammasome activation
ACKNOWLEDGEMENTS I would like to thank my advisors, Drs. William Nauseef and Fayyaz Sutterwala for their support and patience. I would also like to thank my thesis committee for their input. Additionally, I would like to thank everyone in the Inflammation Program. Finally, I would like to thank my family for their endless support. I am especially grateful to my wife Julie for supporting me and ...
متن کاملKdo Hydrolase Is Required for Francisella tularensis Virulence and Evasion of TLR2-Mediated Innate Immunity
UNLABELLED The highly virulent Francisella tularensis subsp. tularensis has been classified as a category A bioterrorism agent. A live vaccine strain (LVS) has been developed but remains unlicensed in the United States because of an incomplete understanding of its attenuation. Lipopolysaccharide (LPS) modification is a common strategy employed by bacterial pathogens to avoid innate immunity. A ...
متن کاملInnate immunity against Francisella tularensis is dependent on the ASC/caspase-1 axis
Francisella tularensis is a highly infectious gram-negative coccobacillus that causes the zoonosis tularemia. This bacterial pathogen causes a plague-like disease in humans after exposure to as few as 10 cells. Many of the mechanisms by which the innate immune system fights Francisella are unknown. Here we show that wild-type Francisella, which reach the cytosol, but not Francisella mutants tha...
متن کاملInnate Immune Recognition of Francisella Tularensis: Activation of Type-I Interferons and the Inflammasome
Francisella tularensis is an intracellular pathogen that can cause severe disease in a wide range of mammalian hosts. Primarily residing in host macrophages, F. tularensis escapes phagosomal degradation, and replicates in the macrophage cytosol. The macrophage uses a series of pattern recognition receptors to detect conserved microbial molecules from invading pathogens, and initiates an appropr...
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ژورنال
عنوان ژورنال: Nature Immunology
سال: 2010
ISSN: 1529-2908,1529-2916
DOI: 10.1038/ni.1859